Makare 5’S

Makare 5's – Combination Therapy with Misoprostol and Mifepristone for Medical Abortion and Pregnancy Termination

Makare 5's is a combination therapy containing Misoprostol and Mifepristone, used for medical abortion and pregnancy termination under supervised healthcare settings. This combination is proven effective in terminating early pregnancies (typically within the first 9 weeks). Mifepristone works by blocking the action of progesterone, a hormone necessary for the pregnancy to continue, leading to the breakdown of the uterine lining. After Mifepristone has initiated the process, Misoprostol is taken to induce uterine contractions, expelling the pregnancy from the uterus.

This treatment is a non-surgical method of abortion, and the two medications are used together to provide a safe and effective solution for women who choose to terminate a pregnancy. The treatment should always be carried out under the supervision of a healthcare provider, who will guide the patient through the process and provide necessary aftercare.

How to Use Makare 5's

• Mifepristone is usually taken first, and typically one tablet (200mg) is administered by the healthcare provider.
• After 24 to 48 hours, Misoprostol is taken, typically as 4 tablets (200mcg each), either orally or vaginally, as per the doctor’s instructions.
• It is important to follow the specific guidance from your healthcare provider regarding dosage and timing.

Precautions

• Medical Supervision: Makare should only be used under the supervision of a qualified healthcare provider. It is essential to have follow-up appointments to ensure the abortion is complete and no complications arise.
• Not Suitable for All Pregnancies: This combination is effective only in the early stages of pregnancy (typically within 9 weeks). It is not suitable for pregnancies outside of the recommended time frame or for certain medical conditions.
• Contraindications: Do not use if you have ectopic pregnancy, adrenal gland disorders, severe anemia, or any history of coagulation disorders, heart disease, or liver problems.
• Pregnancy: Misoprostol and Mifepristone are intended for pregnancy termination and should not be used if you do not wish to end the pregnancy.
• Fertility and Future Pregnancies: This treatment does not affect future fertility, but it is important to follow medical advice for recovery and future family planning.

Possible Side Effects

• Common side effects include cramping, bleeding, nausea, vomiting, and diarrhea, which are typical reactions to the uterine contractions induced by Misoprostol.
• Severe side effects include heavy bleeding (soaking more than two pads per hour for more than two hours), fever, chills, or fainting. If any of these occur, seek immediate medical attention.
• Infection: As with any medical procedure, there is a risk of infection following abortion. Watch for signs such as fever, unpleasant vaginal discharge, or severe pain, and contact your healthcare provider if any of these symptoms arise.