Omastin (Fluconazole) is a triazole antifungal agent. It is a potent and selective inhibitor of fungal cytochrome P450 dependent enzymes necessary for the synthesis of ergosterol.
Indications:
¨ Vaginal Candidiasis.
¨ Oropharyngeal Candidiasis.
¨ Oesophageal Candidiasis.
¨ Systemic Candidiasis and Cryptococcal infection.
¨ Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea.
¨ Kerion.
¨ Pityriasis versicolor.
¨ Onychomycosis.
Other indications:
¨ Fungal urinary tract infections.
¨ Disseminated candidiasis.
¨ Prophylaxis for fungal infection in neutropenic cancer patients.
¨ Acute treatment of other systemic fungal infections such as coccidioidomycosis and histoplasmosis.
How to use
Recommended dosages are given below, and this regimen is recommended from early infection to severe infections. -150 mg as a single dose or 200 mg in 1st day followed by 100 mg daily
for 14 days. -200 mg in 1st day followed by 100 mg daily for 14-30 days. -400 mg in 1st day followed by 200 mg daily for 28 days or longer based on clinical response.
Precautions
Pregnancy: Adverse foetal effects have been seen in animals only at doses ranging from 80 mg/kg to 320 mg/kg with maternal toxicity. These levels are 20-60 times the recommended therapeutic use. Still Fluconazole should be used in pregnancy only if the potential benefit justifies the possible risk to the foetus.
Lactation: Fluconazole is secreted in human milk at concentrations similar to plasma. Therefore, the use of fluconazole in nursing mother is not recommended.
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